Presentation
Sigolène MEILHAC is a developmental biologist and INSERM Research Director, leading since 2015 the team of Heart Morphogenesis jointly affiliated to the Institut Pasteur and Institut Imagine. Trained at the Ecole Normale Supérieure, she obtained a PhD under the supervision of M. Buckingham (Institut Pasteur) in 2003 and carried out post-doctoral work at the Gurdon Institute of Cambridge (UK), as a Marie Curie and EMBO fellow. She was recruited by the INSERM as a tenured researcher in 2006, and, with the support of the young researcher programme of the ANR in 2012, created a research group at the Institut Pasteur. Now located within the campus of the Hospital Necker-Enfants Malades, her team is part of the « ICaRP cardiology » network, that she coordinates to foster interactions between multi-disciplinary expertise in fundamental research and clinics. She is a member of the Board of Reviewing Editors of the journal eLife. She is involved in academic teaching and student supervision, develops scientific workshops for children. Sigolène Meilhac was recipient of the Pasteur Vallery-Radot price in 2018.
Scientific Publications
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Journal (source)Kaufman's Atlas of Mouse Development Supplement, 2nd edEstablishment of a double blood circulation in the developing mouse heart
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Journal (source)Kaufman's Atlas of Mouse Development Supplement, 2nd edSpatiotemporal dynamics of mouse heart tube development
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2023Journal (source)Exp Mol MedOrigin of congenital coronary arterio-ventricular fistulae from anomalous epi...
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2022Journal (source)Curr Opin Genet DevShaping the mouse heart tube from the second heart field epithelium.
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2024Journal (source)Nat CommunInactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity...
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2022Journal (source)Nat Cardiovasc ResPseudodynamic analysis of heart tube formation in the mouse reveals strong re...
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2022Journal (source)Biol Imaging3D cell morphology detection by association for embryo heart morphogenesis.
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2023Journal (source)Dev CellIdentification of Greb1l as a genetic determinant of crisscross heart in mice...
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2023Journal (source)Dev CellIdentification of Greb1l as a genetic determinant of crisscross heart in mice...
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2021Journal (source)Annu Rev Gen Hum GenetHeart Development and Congenital Structural Heart Defects.
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2020Journal (source)Cell RepIntraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 ...
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Journal (source)Philos Trans R Soc Lond B Biol SciMesoderm patterning by a dynamic gradient of retinoic acid signalling.
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2020Journal (source)Dev CellTransient Nodal Signaling in Left Precursors Coordinates Opposed Asymmetries ...
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2012Journal (source)Circ. Res.Lineage tree for the venous pole of the heart: clonal analysis clarifies cont...
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2003Journal (source)DevelopmentA retrospective clonal analysis of the myocardium reveals two phases of clona...
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2004Journal (source)Dev. CellThe clonal origin of myocardial cells in different regions of the embryonic m...
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2004Journal (source)J. Cell Biol.Oriented clonal cell growth in the developing mouse myocardium underlies card...
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2005Journal (source)Nat. Rev. Genet.Building the mammalian heart from two sources of myocardial cells.
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2006Journal (source)DevelopmentSmooth muscle of the dorsal aorta shares a common clonal origin with skeletal...
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2006Journal (source)Dev. Biol.Left and right ventricular contributions to the formation of the interventric...
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2007Journal (source)Dev. Biol.The anterior visceral endoderm of the mouse embryo is established from both p...
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2008Journal (source)Dev. Biol.Myocardium at the base of the aorta and pulmonary trunk is prefigured in the ...
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2009Journal (source)Circ. Res.Landmarks and lineages in the developing heart.
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2009Journal (source)Dev. Biol.Active cell movements coupled to positional induction are involved in lineage...
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2010Journal (source)Circ. Res.Biphasic development of the mammalian ventricular conduction system.
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2010Journal (source)DevelopmentClonal analysis reveals common lineage relationships between head muscles and...
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2011Journal (source)Dev. CellTracing cells for tracking cell lineage and clonal behavior.
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2012Journal (source)Circ. Res.Asymmetric fate of the posterior part of the second heart field results in un...
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Journal (source)Results Probl Cell DifferCell lineages, growth and repair of the mouse heart.
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2013Journal (source)DevelopmentQuantitative analysis of polarity in 3D reveals local cell coordination in th...
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2013Journal (source)Dev. Dyn.Resolving cell lineage contributions to the ventricular conduction system wit...
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2014Journal (source)Med Sci (Paris)[Cilia and heart morphogenesis].
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2015Journal (source)CiliaThe more we know, the more we have to discover: an exciting future for unders...
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Journal (source)Cold Spring Harb Perspect MedCardiac cell lineages that form the heart.
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Journal (source)Wiley Interdiscip Rev Syst Biol MedIntegrating multi-scale knowledge on cardiac development into a computational...
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2015Journal (source)Methods Cell Biol.Imaging and analyzing primary cilia in cardiac cells.
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2017Journal (source)Am. J. Hum. Genet.Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice.
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2017Journal (source)ElifeA predictive model of asymmetric morphogenesis from 3D reconstructions of mou...
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2017Journal (source)Nat CommunAmotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 t...
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2018Journal (source)DevelopmentLeft-right asymmetry in heart development and disease: forming the right loop.
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2018Journal (source)Nat Rev CardiolThe deployment of cell lineages that form the mammalian heart.
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2019Journal (source)Dis Model MechStandardised imaging pipeline for phenotyping mouse laterality defects and as...
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2005Journal (source)Circ. Res.Right ventricular myocardium derives from the anterior heart field.
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2007Journal (source)BMC Dev. Biol.Regionalization of the mouse visceral endoderm as the blastocyst transforms i...
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2013Journal (source)BioinformaticsExtracting 3D cell parameters from dense tissue environments: application to ...