Presentation
Sigolène MEILHAC is Director of Research at INSERM, and Pasteur Vallery-Radot Prize awardee in 2018.
Sigolène MEILHAC is a developmental biologist and INSERM Research Director, leading since 2015 the team of Heart Morphogenesis jointly affiliated to the Institut Pasteur and Institut Imagine. Trained at the Ecole Normale Supérieure, she obtained a PhD under the supervision of M. Buckingham (Institut Pasteur) in 2003 and carried out post-doctoral work at the Gurdon Institute of Cambridge (UK), as a Marie Curie and EMBO fellow. She was recruited by the INSERM as a tenured researcher in 2006, and, with the support of the young researcher programme of the ANR in 2012, created a research group at the Institut Pasteur. Now located within the campus of the Hospital Necker-Enfants Malades, her team is part of the « ICaRP cardiology » network, that she coordinates to foster interactions between multi-disciplinary expertise in fundamental research and clinics. She is a member of the Board of Reviewing Editors of the journal eLife. She is involved in academic teaching and student supervision, develops scientific workshops for children. Sigolène Meilhac was recipient of the Pasteur Vallery-Radot price in 2018.
Resources & publications
-
Journal (source)Dev. Cell
The clonal origin of myocardial cells in different regions of the embryonic m...
-
Journal (source)Circ. Res.
Biphasic development of the mammalian ventricular conduction system.
-
Journal (source)Dev. Biol.
Active cell movements coupled to positional induction are involved in lineage...
-
Journal (source)Circ. Res.
Landmarks and lineages in the developing heart.
-
Journal (source)Dev. Biol.
Myocardium at the base of the aorta and pulmonary trunk is prefigured in the ...
-
Journal (source)Dev. Biol.
The anterior visceral endoderm of the mouse embryo is established from both p...
-
Journal (source)Dev. Biol.
Left and right ventricular contributions to the formation of the interventric...
-
Journal (source)Development
Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal...
-
Journal (source)Nat. Rev. Genet.
Building the mammalian heart from two sources of myocardial cells.
-
Journal (source)J. Cell Biol.
Oriented clonal cell growth in the developing mouse myocardium underlies card...
-
Journal (source)Development
Clonal analysis reveals common lineage relationships between head muscles and...
-
Journal (source)Development
A retrospective clonal analysis of the myocardium reveals two phases of clona...
-
Journal (source)Circ. Res.
Lineage tree for the venous pole of the heart: clonal analysis clarifies cont...
-
Journal (source)Dev Cell
Transient Nodal Signaling in Left Precursors Coordinates Opposed Asymmetries ...
-
Journal (source)Philos Trans R Soc Lond B Biol Sci
Mesoderm patterning by a dynamic gradient of retinoic acid signalling.
-
Journal (source)Cell Rep
Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 ...
-
Journal (source)Annu Rev Gen Hum Genet
Heart Development and Congenital Structural Heart Defects.
-
Journal (source)Dev Cell
Identification of Greb1l as a genetic determinant of crisscross heart in mice...
-
Journal (source)Dev Cell
Identification of Greb1l as a genetic determinant of crisscross heart in mice...
-
Journal (source)Wiley Interdiscip Rev Syst Biol Med
Integrating multi-scale knowledge on cardiac development into a computational...
-
Journal (source)BMC Dev. Biol.
Regionalization of the mouse visceral endoderm as the blastocyst transforms i...
-
Journal (source)Circ. Res.
Right ventricular myocardium derives from the anterior heart field.
-
Journal (source)Dis Model Mech
Standardised imaging pipeline for phenotyping mouse laterality defects and as...
-
Journal (source)Nat Rev Cardiol
The deployment of cell lineages that form the mammalian heart.
-
Journal (source)Development
Left-right asymmetry in heart development and disease: forming the right loop.
-
Journal (source)Nat Commun
Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 t...
-
Journal (source)Elife
A predictive model of asymmetric morphogenesis from 3D reconstructions of mou...
-
Journal (source)Am. J. Hum. Genet.
Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice.
-
Journal (source)Methods Cell Biol.
Imaging and analyzing primary cilia in cardiac cells.
-
Journal (source)Bioinformatics
Extracting 3D cell parameters from dense tissue environments: application to ...
-
Journal (source)Cold Spring Harb Perspect Med
Cardiac cell lineages that form the heart.
-
Journal (source)Cilia
The more we know, the more we have to discover: an exciting future for unders...
-
Journal (source)Med Sci (Paris)
[Cilia and heart morphogenesis].
-
Journal (source)Dev. Dyn.
Resolving cell lineage contributions to the ventricular conduction system wit...
-
Journal (source)Development
Quantitative analysis of polarity in 3D reveals local cell coordination in th...
-
Journal (source)Results Probl Cell Differ
Cell lineages, growth and repair of the mouse heart.
-
Journal (source)Circ. Res.
Asymmetric fate of the posterior part of the second heart field results in un...
-
Journal (source)Dev. Cell
Tracing cells for tracking cell lineage and clonal behavior.